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KMID : 1156220160420010027
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Journal of Environmental Health Sciences
2016 Volume.42 No. 1 p.27 ~ p.33
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Toxic Effects of Alumina Nanoparticles in Rat Cerebrums and Kidneys
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조은혜:Jo Eun-Hye
서균백:Seo Gyun-Baek/김현미:Kim Hyun-Mi/최경희:Choi Kyung-Hee/권정택:Kwon Jung-Taek/김필제:Kim Pil-Je/엄익춘:Eom Ig-Chun
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Abstract
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Objectives: Alumina nanoparticles (Al2O3, Al-NPs) are used for various purposes, including as coating agents and paint additives. Their potential toxicity has raised concern for human health. This study focuses on exploring the toxic effects on the brain and kidneys caused by Al-NPs exposure in rats.
Methods: The animals were orally administered Al-NPs at 10, 50 and 100 mg/kg body weight for 28 days following OECD TG 407. To determine the targeted toxicity of Al-NPs, histopathological examination and gene expression analysis were conducted on the rats.
Results: The Al-NPs treatment induced kidney tubular dilatation. In the rat cerebrums, the expression levels of 126 genes experienced two-fold or greater increases in response to Al-NPs, including other genes encoding proteins involved in cell differentiation, transcription and signal transduction. In the rat kidneys, the expression levels of 152 genes also showed two-fold or greater increases in response to Al- NPs, including other genes encoding proteins involved in apoptosis, transcription and signal transduction.
Conclusion: These results suggest that exposure to Al-NPs influences cellular signal pathways of kidney and cerebrum, and it can be a toxic indicators of nanometrials.
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KEYWORD
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Aluminum oxide, nanoparticles, toxicogenomics
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